Oriol Bárcenas

To integrate LLPS proteins into complete specific categorical datasets, we compiled data from the most recognized LLPS resources. Since different databases provide varying levels of evidence for the collected data, our first step implied the design of standardized filters aligned with LLPS vocabulary definitions to generate a curated group of proteins with consistent levels of confidence for all protein categories.

1 INTRODUCTION Protein aggregation is a significant biochemical process with implications for both health and technology. It occurs when soluble proteins form insoluble aggregates, often leading to diseases such as Parkinson's, Alzheimer's, ALS, type II diabetes, and various cancers (Chiti & Dobson, 2017). From an evolutionary perspective, protein aggregation can limit the diversity of protein sequences that can be stably expressed in cells.

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