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Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity

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By Christine Lawson, Samuel Rouleau, Lee-Hwa Tai, Orneala Bakos
| Biomed Central (BMC)
]. At the cellular level, surgery-induced necrotic cell death leads to the release of sequestered cellular factors. These factors make up the “alarmins” that alert the immune system to the presence of tissue damage. Following the detection of alarmins by pathogen recognition receptors, innate immune cells initiate inflammatory pathways, chemotaxis, antimicrobial defenses, and adaptive immune cell responses [ ].
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