Osamu Muto on Muck Rack

Osamu Muto

As seen in: Nature, MDPI
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Articles

Low-frequency CD8+ T cells induced by SIGN-R1+ macrophage-targeted vaccine confer SARS-CoV-2 clearance in mice - npj Vaccines

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By Daisuke Muraoka, Osamu Muto, Rui Yamaguchi
| Nature Verified
Abstract Vaccine-induced T cells and neutralizing antibodies are essential for protection against SARS-CoV-2. Previously, we demonstrated that an antigen delivery system, pullulan nanogel (PNG), delivers vaccine antigen to lymph node medullary macrophages and thereby enhances the induction of specific CD8+ T cells. In this study, we revealed that medullary macrophage-selective delivery by PNG depends on its binding to a C-type lectin SIGN-R1.
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JCM | Free Full-Text | Correlation of UGT1A1 Gene Polymorphisms or Prior Irinotecan Treatment and Treatment Outcomes of Nanoliposomal-Irinotecan plus 5-Fluorouracil/Leucovorin for Pancreatic Ductal Adenocarcinoma: A Multicenter, Retrospective Cohort Study

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By Michio Nakamura, Kazuaki Harada, Takahiro Yamamura, Osamu Muto
| MDPI
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