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To validate the PET probe in the clinic, we initiated an observational clinical study (platelet-derived growth factor receptor ß [PDGFRß] imaging in cardiac fibrosis - PARIS trial: https://clinicaltrials.gov/ ID: NCT06956560) in which patients with STEMI were examined 1 week and 2 months after PCI using PET in combination with magnetic resonance imaging (MRI). 68Ga-ATH001 was synthesized under GMP conditions with a radiochemical purity of 98.1% ± 0.7%.
Abstract A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein profiling to explore the proteome signature in blood across patients representing many of the major cancer types.
Originally publishedCirculation. 2022;0:10.1161/CIRCULATIONAHA.122.060125 Abstract BACKGROUND: Differences in adverse cardiac remodeling between patients who have bicuspid (BAV) and tricuspid aortic valve (TAV) with severe isolated aortic stenosis (AS) and its prognostic impact after surgical aortic valve replacement remains unclear.
Abstract Background Airway hyperresponsiveness (AHR) is a feature of asthma in which airways are hyperreactive to stimuli causing extensive airway narrowing. Methacholine provocations assess AHR in asthma patients mainly by direct stimulation of smooth muscle cells. Using in vivo mouse models, mast cells have been implicated in AHR, but the mechanism behind has remained unknown.
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