Osman Nuri Keles on Muck Rack

Osman Nuri Keles

As seen in: Nature
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Pomiferin protects against sepsis-associated acute liver and kidney injury via inhibition of NF-κB activation, oxidative stress, and cytochrome-c

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By Mohammad Alhilal, Huseyin Erol, Serkan Yildirim, Murat Koc, Esra Dereli, Ilyas Bozkurt, Suzan Alhilal, Tuba Karaarslan, Esra Aktas Senocak, Osman Nuri Keles, Mesut Bunyami Halici
| Nature
Abstract In this study we report the first identification of the therapeutic effects of pomiferin isolated from Maclura pomifera against acute liver and kidney injury induced by sepsis. These results were obtained using a rat model of sepsis. We focused on targeting the nuclear factor kappa B (NF-κB) activation cascade, oxidative stress, and cytochrome-c, three key components involved in the pathophysiology of sepsis-associated acute liver and kidney injury.
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