Ouali Berkani

Systemic lupus erythematosus Pharmacodynamics of the S1P1 receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Bioinformatics analysis Sequencing reads were processed using Nextflow (V.21.10.6) nf-core RNAseq pipeline V.3.3.14 STAR (V.2.6.1d) was used to align reads to human genome version GRCh38_98 and gene expression count tables were generated using Salmon (V.1.4.0).15 Raw counts were normalised using variance stabilising transformation (vst function from DESeq2 package). To evaluate dose-dependent molecular changes we used gene signatures summarised into z-scores.