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As seen in: Frontiers in Immunology
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Case Report: Complete metabolic responses to trastuzumab–deruxtecan in HER2-altered solid tumors: two illustrative cases

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By Le Meur, Le Roux, Ouest Pathologie Brest
| Frontiers in Immunology
Abstract Background: Human epidermal growth factor receptor-2 (HER2) alterations, including activating mutations and gene amplification, are emerging therapeutic targets in several solid tumors. Trastuzumab–deruxtecan (T-DXd), a HER2-directed antibody-drug conjugate (ADC), has demonstrated antitumor activity across multiple HER2-altered cancers.
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