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Oussama El Baraka

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Articles

Hydrodynamically generated multilayer skin spheroids enable in vitro screening of biologically active ingredients and toxicity tests

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By Barbara von Hippel, Jinke Chang, Elena Emili, Zhengkun Chen, Faeze Rakhshani, Liangliang Qu, Susanne Kolle, Valerie Andre, Ted Deisenroth, Eugenia Kumacheva, Dianoosh Kalhori, Oussama El Baraka
| Science Magazine Verified
Abstract Human tissues often have a multilayer structure, with each layer performing a distinct physiological task. Reconstructing layered tissue structures with their respective functions is crucial for disease modeling, screening biologically active ingredients, and performing toxicology tests; however, multicellular spheroids used for these purposes generally lack a well-defined multilayer architecture.
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