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Articles by Outcomes Research
A Prediction Model for Disease-Free Survival Following R0/R1 Rectal Cancer Resection: A Retrospective Longitudinal Study Based on the Norwegian and Danish Colorectal Cancer Quality Registries
Keywords Rectum Cancer Prediction Model Postoperative Management Get full text access Log in, subscribe or purchase for full access. References: 1. Bray, F. ∙ Laversanne, M. ∙ Sung, H. ... Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA: A Cancer Journal for Clinicians. 2024; 74(3):229-263 2. Wibe, A. ∙ Møller, B. ∙ Norstein, J. ...
ISPOR’s “HEOR Explained” and “HEOR News Desk” Win Major Industry Awards
The award-winning videos are featured assets on ISPOR’s HEOR Explained website designed to help people better understand how health economics and outcomes research (HEOR) can improve healthcare decisions. The HEOR Explained video was developed in partnership with its communications agency Taft Communications, a division of RF|Binder. ISPOR’s HEOR News Desk was created as a central hub to share the latest updates, insights, and stories in HEOR.
Risk of kidney failure and death associated with target-dose (vs. below-target-dose) RAS inhibitors in HFrEF, HFmrEF and HFpEF: Spline-based reassessment of subgroup findings
Affiliations & Notes aCenter for Data Science and Outcomes Research, Veterans Affairs Medical Center, Washington, DC, USA bGeorgetown University,Washington, DC, USA cGeorge Washington University, Washington, DC, USA dUniformed Services University, Washington, DC, USA eVeterans Affairs Medical Center, Providence, RI, USA fBrown University, Providence,RI, USA gUniversity of Alabama at Birmingham, Birmingham, AL, USA hMedStar Washington Hospital Center, Washington, DC, USA iVeterans Affairs Palo...
Hospital-Treated Severe Hypoglycemia in Type 1 Diabetes in the US: A Retrospective Claims-Based Study of Diabetes-Related Complications and Direct Medical Costs | Advances in Therapy | Springer Nature Link
Data Source This retrospective cohort study utilized administrative claims data from IQVIA’s PharMetrics Plus database to identify pwT1D from April 1, 2016, through April 30, 2020. The overall study period was October 1, 2015, to April 30, 2022, to allow at least two years of follow-up.
ISPOR Publishes Health Economics and Outcomes Research Competencies Framework
The field of HEOR has grown substantially in the past 20 years. Because of the dynamic nature of the discipline and external influencing factors, there is a need to provide guidance to uniquely skilled professionals with HEOR backgrounds to equip them with tools to create, implement, and evaluate the different aspects of HEOR. Through collaboration among multiple ISPOR groups, the competencies can be used to highlight areas for career growth.
Health Equity Research Goes Global—Without Waiting for Perfect Data | Newswise
Health Equity Research Goes Global—Without Waiting for Perfect Data International Studies in Value in Health Regional Issues Show How Countries Can Advance Equity Using Practical Tools and Local Insights Newswise — Lawrenceville, NJ, USA—February 9, 2026— Value in Health Regional Issues, a journal of ISPOR—The Professional Society for Health Economics and Outcomes Research, announced today the publication of a special collection of research papers in showing that meaningful progress in health...
International Study Confirms Universally Applicable Framework for Defining Digital Health Interventions
Digital health interventions continue to proliferate, with much of the growth in patient-facing applications; however, their potential has yet to be fully realized in clinical practice. International, regional, and national health organizations are facilitating the integration of digital innovations into healthcare systems, while seeking to minimize risks to patient safety and privacy.
ISPOR Releases New 2026-2027 Top 10 HEOR Trends Report
Artificial intelligence (AI) moves to the #1 spot on the trends list. AI is rapidly transforming healthcare and HEOR, creating new opportunities and challenges for responsible implementation. Real-world evidence (RWE) moves to #2 after appearing as the top trend in the past several reports. With the expanded use of RWE in regulatory assessments, the focus is centering on enhancing the availability, quality, and transparency of real-world data.
LDL-C Goal Attainment with Fixed-Dose Ezetimibe and Atorvastatin Versus High-Dose Atorvastatin in Chinese Patients: Subgroup Analysis of a Randomized Trial | Advances in Therapy | Springer Nature Link
World Health Organization (WHO). Cardiovascular diseases. 2025. https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1. Accessed 12 June 2025. Wang W, Liu Y, Ye P, et al. Trends and associated factors in place of death among individuals with cardiovascular disease in China, 2008–2020: a population-based study. Lancet Reg Health. 2022;21:100383–100383. Google Scholar Writing Committee of the Report on Cardiovascular Health and Diseases in China.
ISPOR Announces New Executive Director for the ISPOR Institute for Healthcare Transformation
Ms Saldaña joins ISPOR with more than 2 decades of leadership experience in shaping health systems and public health policy across international development, government, and private sectors. Most recently she was vice president of global health at Abt Global, a mission-driven consulting and research firm working to improve the quality of life and economic well-being of people worldwide.
The Balancing Act of Paid Work and Caregiving in Duchenne Muscular Dystrophy (DMD): Results from a Cross-sectional Survey - Advances in Therapy
Study Design Caregivers of individuals with DMD living in the US completed a cross-sectional, web-based survey between March–May 2023. This study was performed in accordance with the Helsinki Declaration of 1964 and its later amendments and received ethical approval from the Western-Copernicus Group Institutional Review Board (IRB; #20,230,733). Electronic consent was collected prior to survey initiation.
A study protocol for a multi-specialty observational cohort comparing robotic stapler and bedside stapler outcomes in robotic-assisted surgeries
Loading metrics Open Access Study Protocol Citation: Chi Y-T, Hamm NC, Lee S-H, Shin M, Liu Y, Shih I-F, et al. (2025) A study protocol for a multi-specialty observational cohort comparing robotic stapler and bedside stapler outcomes in robotic-assisted surgeries. PLoS One 20(12): e0339191.
Robotic Assisted versus Laparoscopic Duodenal Switch Procedures: A Nationwide Propensity Score Matched Analysis
Keywords Robotic laparoscopic duodenal switch perioperative outcomes cost Get full text access Log in, subscribe or purchase for full access. REFERENCES 1. Ward, Z.J. ∙ Bleich, S.N. ∙ Cradock, A.L. ... Projected U.S. State-Level prevalence of adult obesity and severe obesity N Engl J Med. 2019; 381:2440-2450 2. Courcoulas, A.P. ∙ King, W.C. ∙ Belle, S.H. ... Seven-year weight trajectories and health outcomes in the longitudinal assessment of bariatric surgery (LABS) study JAMA Surg.
Cardiovascular disease in people living with HIV in Malaysia: A competing risks cohort analysis
Purpose Cardiovascular disease (CVD) is an emerging health concern among people living with HIV (PLHIV), particularly in Asian settings where evidence remains limited. We aimed to estimate the cumulative risk of CVD among PLHIV in Malaysia, in the presence of competing risk from non-CVD deaths, and to identify associated risk factors.
A Systematic Review of the Methods and Quality of Economic Evaluations for AI-assisted Cancer Screening or Diagnosis
Systematic Literature ReviewArticles in PressOpen access 1School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China 2School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China 3School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China 4School of Pharmacy, Taylor's University, Subang Jaya, Malaysia 5School of International Pharmaceutical Business, China...
ISPOR Announces Launch of ISPOR Institute for Healthcare Transformation
Healthcare systems across the globe are challenged by myriad crises, including budget constraints, paying for innovative new therapies, aging populations, workforce challenges, and global catastrophes that include war and climate change. The ISPOR Institute for Healthcare Transformation is an organic extension of ISPOR that bridges the gap between research and real-world application to further elevate the relevance, use, and impact of HEOR.
New Research Collection Reveals How Artificial Intelligence Is Reshaping Health Economics
Newswise — Lawrenceville, NJ, USA—November 6, 2025—The PhRMA Foundation and ISPOR—The Professional Society for Health Economics and Outcomes Research announced today the publication of a special themed section of research papers that explores the dynamic intersection of artificial intelligence (AI) and health economics and outcomes research (HEOR). Additionally, the PhRMA Foundation will provide $5000 Trainee Challenge Awards to 4 first authors whose papers appear in the themed section.
Should Gleason 6 Still Be Considered Cancer? A Narrative Review of its Biology and Clinical Course, with Implications for Guideline Recommendations and Practice Implementation
Keywords Prostate cancer Gleason 6 Active surveillance Overtreatment Clinical guidelines Patient communications Get full text access Log in, subscribe or purchase for full access. References 2. Bray, F. ∙ Laversanne, M. ∙ Sung, H. ... Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin. 2024; 74:229-263 3. Wilt, T.J. ∙ Vo, T.N. ∙ Langsetmo, L. ...
ISPOR Announces 2025 Health Economics and Outcomes Research Award Honorees
The 2025 HEOR Award honorees include: ISPOR Impact Award Established in 2025, this new award recognizes examples of HEOR delivering outstanding impact in healthcare.
The Ozempic Paradox: How Spending Billions on Weight-Loss Drug Would Actually Reduce Overall Medicare Costs
Newswise — Lawrenceville, NJ, USA—October 14, 2025—Value in Health, the official journal of ISPOR—The Professional Society for Health Economics and Outcomes Research, announced today the publication of a landmark study by researchers at the University of Washington, Curta, Inc, and the University of North Carolina showing that broad Medicare coverage of semaglutide in diabetes, obesity, and liver disease could generate significant cost savings while delivering substantial health benefits to...
ISPOR Europe 2025 Plenaries and Speakers Announced
Joining ISPOR CEO Rob Abbott is this year’s keynote speaker David Snowden, Founder and Chief Scientific Officer of The Cynefin Co. Together they will explore global collaboration and complexity in advancing patient-centered healthcare decision making. Plenary sessions for ISPOR Europe 2025 include the following with speakers added to the online program as they are confirmed: Plenary 1: Patient Engagement in Healthcare Investments—A Promise or a Practice?
ISPOR Launches New Content on Whole Health
ISPOR's Strategic Plan 2030 introduced the Society's new vision for a world where healthcare is accessible, effective, efficient, and affordable for all. An integral element of this strategy is viewing health through a more holistic lens that looks at all the key factors that impact an individual's health—whole health. Whole health expands the definition of value by recognizing the physical, behavioral, socioeconomic, environmental, and spiritual dimensions of health.
Landmark Analysis in Value in Health Uncovers Potential Research Efficiency Gains | Newswise
Led by a global team of health preference research experts—Michael Bui, Karin Groothuis-Oudshoorn, Cecilia Jimenez-Moreno, Byron Jones, Conny Berlin and Janine van Til—the review addresses a critical question in healthcare policy: do we always need to conduct new patient preference studies, or can findings from previous studies be transferred or synthesized for use in new decision-making contexts?
Healthcare Costs Associated with Adverse Events in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder (ADHD): A Claims-Based Study - Advances in Therapy
Abstract Adverse events (AEs) are common in pediatric patients receiving attention-deficit/hyperactivity disorder (ADHD) treatment; however, real-world studies on their costs from a payer’s perspective are lacking. Therefore, this study investigated the healthcare costs associated with selected AEs among pediatric patients receiving ADHD treatment in the United States.
ISPOR Real-World Evidence Summit 2025 28-30 September 2025 | Tokyo, Japan | Newswise
The Summit features plenary sessions, workshops, and breakout discussions on today’s most pressing topics, each tied to the bigger picture of real-world evidence (RWE) including health equity, HTA, value-based healthcare, generative AI, health policy, drug price negotiations, and beyond.
"Most-Favored Nation" Drug Pricing Strategy May Backfire, New Research Warns | Newswise
Led by researchers at the CHOICE Institute and Camber Collective, the commentary examines the outcomes of international reference pricing across European Union countries and finds that while such policies initially provided short-term budget savings, they ultimately led to price convergence around major high-income markets rather than sustainable price reductions.
Preoperative focused echocardiography on patients with fractured neck of femur. ECHONOF-III trial: study protocol for a multicenter randomized controlled trial | Trials | Full Text
1. Ximena Cid-Serra Email: x.cidserra@unimelb.edu.au Affiliations: Department of Surgery, The University of Melbourne, Melbourne, Australia Department of General Medicine, The Royal Melbourne Hospital, Melbourne, Australia 2. Alistair Royse—cardiothoracic surgeon Department of Surgery, The University of Melbourne, Melbourne, Australia 3.
A systematic review of the willingness-to-accept and willingness-to-pay disparities in empirical studies in the healthcare field - Archives of Public Health
This study aimed to systematically review the available evidence regarding the disparity between WTA and WTP for health outcomes or healthcare goods and services. The results of empirical studies may be influenced by the selected methods of value elicitation, specifically concerning WTA and WTP questions.
Frontiers | “You’re never going to get a second chance if someone doesn’t give you a second chance” perspectives and experiences of landlords and advocates on implementing HOME among youth experiencing homelessness
Introduction Each year, 3.5 million youth (ages 18–25) experience homelessness in the United States (1, 2). Youth experiencing homelessness (YEH) are a marginalized population (3) and often have prior legal system involvement (LSI) (4–6).
Identity with Diabetes: Unpacking an Overlooked but Essential Dimension of the Diabetes Experience - Current Diabetes Reports
Abstract Identity is a fundamental, but understudied, aspect of the diabetes experience. Diabetes imposes many life changes, which likely impact self-perception. The current review explores the concept of identity with diabetes, implications for health, and processes to facilitate a positive identity. Identity with diabetes has been explored as a dimension, process, and outcome.
Epidemiology of hepatitis delta virus (HDV) infection and comparison of clinical characteristics and disease progression among patients with HDV vs. hepatitis B mono-infection: real-world data from a large healthcare insurer-provider in Israel | Virology
A retrospective cohort study was performed using anonymized data extracted from the Maccabi Healthcare Services (MHS) database. MHS is one of four state-mandated healthcare insurer-providers in Israel, covering approximately a quarter of the population nationwide. The MHS database contains more than two decades of longitudinal data on > 2.7 million people (1.8 million adults) since 1998, with similar demographics to the national population and a high retention rate (> 98%/year).
ISPOR Champions Research Transparency With Launch of Open Science Badges
Newswise — Lawrenceville, NJ, USA—August 4, 2025—ISPOR—The Professional Society for Health Economics and Outcomes Research (HEOR) today introduced an initiative to recognize transparency in research for papers published in Value in Health, its preeminent HEOR journal.
Sight Sciences Announces the Results of a Cost-Utility Analysis Demonstrating Cost Savings and Greater Health Utility with the TearCare® System Compared to Cyclosporine 0.05% for Treating Meibomian Gland Disease-Associated Dry Eye Disease () | aktiencheck
30.07.25 13:00 GlobeNewswire Cost-Utility Analysis published in the Expert Review of Pharmacoeconomics and Outcomes Research Cost-Utility Analysis published in the Expert Review of Pharmacoeconomics and Outcomes Research zur Originalmeldung Alle Aktien des Tages Aktienanalysen News Kolumnen Videos Sprache
ELEVATE-GenAI: Reporting Guidelines for the Use of Large Language Models in Health Economics and Outcomes Research: an ISPOR Working Group on Generative AI Report
1Value Analytics Labs, Cambridge, MA, United States 2Office of the Director, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, United States 3National Institute for Health and Care Excellence, London, United Kingdom 4Cairo University, Faculty of Pharmacy, Cairo, Egypt 5Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, FL, United States 6Biomedical Informatics, Clinical and Translational Science...
Sensitivity and specificity of various lung function parameters recommended for phenotyping COPD in clinical practice.
Key words COPD phenotypes emphysema spirometry DLCO and DLNO diffusion lung capillary blood volume Get full text access Log in, subscribe or purchase for full access. References 1. Celli, B. Am. J. Respir. Crit. Care Med. 2022; 206:1317-1325 2. Mannino, D.M. ∙ Higuchi, K. ∙ Yu, T.C. ... Economic burden of chronic obstructive pulmonary disease by presence of comorbidities Chest. 2015; 147:199-201 3. Iheanacho, I. ∙ Zhang, S. ∙ King, D. ...
Racial, ethnic, sex, and age representation in clinical trials of radiopharmaceutical tumor therapy: a systematic review and meta-analysis - BMC Cancer
This study conducted data retrieval from PubMed and Web of Science (via the MEDLINE database), covering the period from the inception of the databases through November 2024, with additional searches performed on ClinicalTrials.gov. The search strategy and inclusion criteria are detailed in the eMethods, Supplement 1. This study used only publicly available data, and no patients were involved.
Maternal awareness of newborn danger signs before discharge: a secondary analysis of baseline data from a quasi-experimental study in Uganda - Maternal Health, Neonatology and Perinatology
Abstract The neonatal period is the most vulnerable time for children under 5 years. Neonatal mortality contributes to almost one-half of all under-5 deaths. Developing one or more newborn danger signs increases the mortality risk in the first 28 days of life. Understanding maternal awareness of newborn danger signs is essential in promoting early newborn care-seeking for better outcomes.
ISPOR Takes Health Research Mainstream With Plain Language Summaries | Newswise
The Plain Language Summaries program transforms published research articles from ISPOR’s preeminent HEOR journal—Value in Health—into clear, nontechnical summaries that can be easily understood by laypeople, regardless of their expertise in health economics or clinical research.
Economic Burden of Postsurgical Chronic Hypoparathyroidism: A US Medicare Claims Retrospective Analysis - Advances in Therapy
Abstract Approximately 75% of hypoparathyroidism (HypoPT) cases result from removal of or injury to parathyroid glands during anterior neck surgery. HypoPT persisting 6 months following surgery carries a significant economic burden. This study aims to describe the economic burden of postsurgical chronic HypoPT in the Medicare population.
Mapping the Open Source Revolution in Health Economics | Newswise
"Health economic models underpin health technology assessment, which is used to assess the value of an intervention for a given disease," noted author Raymond H. Henderson, PhD, Senior Health Technology Assessment Manager, Salutem Insights Ltd, Ireland.
ISPOR’s “HEOR Explained” Video Recognized With 2025 Telly Award
Newswise — Lawrenceville, NJ, USA—June 10, 2024—ISPOR—The Professional Society for Health Economics and Outcomes Research announced that its “HEOR Explained” video was recognized with a Bronze 2025 Telly Award in the Non-Broadcast: General Explainer category. The award-winning video is a featured asset on ISPOR’s HEOR Explained website that is designed to help people better understand how health economics and outcomes research (HEOR) can improve healthcare decisions.
Characterization of Japanese Risk Management Plans after 10 Years of Implementation: 2013–2023 - Therapeutic Innovation & Regulatory Science
Abstract A decade since Japan introduced risk management plans offers an opportunity to analyze their characteristics and support future pharmacovigilance efforts. To describe (1) the types of post-marketing studies (PMSs) and the number of safety concerns and efficacy concerns by drug classification and (2) the distribution of important identified and important potential risks by type of safety concern.
Epidemiology, patient management, and survival outcomes in resected patients with non-metastatic non-small cell lung cancer: a nationwide real-world study | BMC Cancer | Full Text
The study population included 57, 801 patients with non-metastatic NSCLC who underwent a first LR between 2015 and 2020 (Fig. 1). Patient disposition– study population The annual number of patients increased by an average of 4.5% per year between 2015 (n = 8,688) and 2019 (n = 10,330) and decreased to 9,551 in 2020 (COVID-19 pandemic year).
ISPOR Announces 2025-2026 Board of Directors
Uwe Siebert, MD, MPH, MSc, ScD—President Dr Siebert will assume the role of 2025-2026 president after serving as ISPOR’s president-elect over the past year. He is professor of Public Health, Medical Decision Making, and Health Technology Assessment (HTA), and chair of the Department of Public Health, Health Services Research, and HTA at UMIT TIROL - University for Health Sciences and Technology in Austria.
Value in Health Journal Spotlights "Whole Health" in Special Series
Newswise — Lawrenceville, NJ, USA—May 19, 2025—Value in Health, the official journal of ISPOR—The Professional Society for Health Economics and Outcomes Research, announced today the publication of a series of articles exploring the concept of "whole health"—a holistic approach to healthcare that extends beyond the traditional biomedical model to incorporate physical, mental, social, environmental, and spiritual dimensions of wellbeing.
New Research Reveals Surprising Trends in Women's Health Economics Authorship | Newswise
“While women continue to be underrepresented in authorship of scientific research generally, there has been no evidence to date on how well women are represented in authorship of papers in the field of health economics and outcomes research (HEOR) and whether that representation was affected by the COVID pandemic,” said first author Sumie Kakehi, PharmD, School of Public Health, Rutgers University, Piscataway, New Jersey, USA.
Rethinking Medication Adherence: A Stakeholder Blueprint | Newswise
"The prevalence of nonadherence to prescription medication can be as high as 50%," said author Bijan Borah, PhD, Professor of Health Services Research, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, and the current Chair of the ISPOR Special Interest Group on Medication Adherence and Persistence.
Shifting perspectives: a reflection on cancer-specific quality-of-life metrics in cancer care economics
aDepartment of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital of Psychiatry II, Medial University of Innsbruck, 6020 Innsbruck, Austria bSchool of Psychology, University of Sydney, Camperdown, NSW, Australia cGlobal Health Economics and Outcomes Research, Bristol Myers Squibb, Lawrenceville, NJ, USA dDepartment of Health Economy, Norwegian Medicines Agency, Oslo, Norway eCenter for Health Technology Assessment and Center for Pharmacology and Drug Research and...
Cost-Effectiveness Analysis of SGLT2 Inhibitors for Cardio-Renal-Metabolic Disease Based on Data from Japanese Studies - Advances in Therapy
Abstract Cardiovascular, renal, and metabolic diseases, collectively known as cardio-renal-metabolic (CRM) disease, interact and exacerbate each other, creating serious clinical and economic burdens. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are important therapeutic agents in managing CRM disease. Despite proven clinical benefits, the economic benefits of SGLT2i in the management of CRM diseases remain unclear.
ISPOR Publishes Insights From Its First Global HTA Roundtable
The virtual ISPOR Global HTA Roundtable convened 100 HTA professionals from 53 countries around the world in Q4 2024 to connect, share best practices, and build consensus on global HTA standards. The Roundtable participants focused on 3 key topics: (1) gene therapies and other advanced therapy medicinal products (ATMPs), (2) improving access to therapies while navigating budget constraints, and (3) digital health with a focus on artificial intelligence (AI).
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