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Ovidio Bussolati on Muck Rack

Ovidio Bussolati

As seen in: Nature
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Articles

High glutamate levels in the bone marrow of multiple myeloma patients promote osteoclast formation: a novel target for osteolytic bone disease - Leukemia

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By Giuseppe Taurino, Mattia Dessena, Ovidio Bussolati
| Nature Verified
Abstract Multiple Myeloma (MM) is a glutamine (Gln)-addicted cancer. Consequently, the MM bone microenvironment (BM) is characterized by lower Gln and higher glutamate (Glu) levels than those in pre-malignant monoclonal gammopathies. Such MM-dependent metabolic perturbation impairs osteoblast differentiation in the bone microenvironment, but its effect on osteoclast (OCL) bone resorption is still unknown.
Open in Who Shared Issue with article?

Genetic strategies for sex-biased persistence of gut microbes across human life - Nature Communications

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By Giuseppe Taurino, Miguel Gueimonde, Douwe van Sinderen, Christian Milani, Ovidio Bussolati
| Nature Verified
Abstract Although compositional variation in the gut microbiome during human development has been extensively investigated, strain-resolved dynamic changes remain to be fully uncovered. In the current study, shotgun metagenomic sequencing data of 12,415 fecal microbiomes from healthy individuals are employed for strain-level tracking of gut microbiota members to elucidate its evolving biodiversity across the human life span.
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