Owens Uwangue on Muck Rack

Owens Uwangue

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Articles

Exploring serial crystallography for drug discovery

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By Cindy Phan, Owens Uwangue, Andreas Dunge, Monika Bjelcic
| biorxiv.org
Abstract Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical drug candidate. A limitation of the main structural method used today, rotational cryo-crystallography, is that it only provides structural information of the protein-complex in its frozen state.
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