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Özlem Küçükhüseyin on Muck Rack

Özlem Küçükhüseyin

As seen in: Nature
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Articles

Integrated assessment of IDO1 activity and PD L1 expression reveals immunometabolic alterations in non small cell lung cancer

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By Mehmet Hakan, Ümit Zeybek, Ceylan Hepokur, Zuhal Hamurcu, Akif Turna, Bulent Ozpolat, İlhan Yaylim, Şeyda Demirkol, Dilara Sönmez Zor, Cem Horozoğlu, Özlem Küçükhüseyin
| Nature Verified
Abstract IDO1 contributes to tumor-associated immunosuppression by regulating tryptophan catabolism. This study investigated the immunometabolic tryptophan-kynurenine axis in NSCLC by evaluating circulating tryptophan metabolites, the IDO1 rs10089084 genetic variation, IDO1/PD-L1 expression in tumor tissues of NSCLC patients, and soluble sPD-1 in relation to clinicopathological features. Seventy NSCLC patients and 72 healthy controls were included in the study.
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