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P. Adolfo Sequeira on Muck Rack

P. Adolfo Sequeira

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Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia - Translational Psychiatry

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By Megan Hastings Hagenauer, Evan Hughes, P. Vawter, Francis Lee, Alan F. Schatzberg, Adriana M. Medina, Maria Waselus, P. Adolfo Sequeira
| Nature Verified
Abstract The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to the age of onset for bipolar disorder (BP) and schizophrenia (SCHIZ), and its dysfunction is likely to underly aspects of their shared symptomology. In this study, we investigated the role of BA10 neurotransmission-related gene expression in BP and SCHIZ.
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