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P. Barthelemy on Muck Rack

P. Barthelemy

As seen in: Annals of Oncology
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Articles

TiNivo: safety and efficacy of tivozanib-nivolumab combination therapy in patients with metastatic renal cell carcinoma

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By L. Albiges, Gustave Roussy, P. Barthelemy, M. Gross-Goupil
| annalsofoncology.org
Background Treatment with tivozanib, a highly selective and potent vascular endothelial growth factor receptor tyrosine kinase inhibitor, has demonstrated single-agent efficacy in advanced renal cell carcinoma (RCC) along with minimal off-target toxicities and a favorable adverse event (AE) profile. We report final results from TiNivo, a phase Ib/II study of tivozanib combined with nivolumab.
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Denosumab in patients with bone metastases from renal-cell carcinoma treated with anti-angiogenic therapy: a retrospective study from the GETUG (Groupe Etude des Tumeurs Uro Genitales)

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By A. Guillot, CHU Henri Mondor, C. Joly, P. Barthelemy
| Annals of Oncology Verified
Background: Metastatic renal-cell carcinoma (mRCC) treatment relies on anti-angiogenic therapies. Bone metastases occur in nearly 30% of mRCC and can induce symptomatic skeletal-events (SSE) such as pain requiring radiotherapy, pathologic fractures, and spinal cord compression. SSE can be prevented using bone-targeted agents, e.g. bisphosphonates or denosumab. Data about denosumab and anti-angiogenic combination are scarce.
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