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P. G. Bardin on Muck Rack

P. G. Bardin

As seen in: Color Research & Application, Annals of Allergy, Asthma & Immunology
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Articles

P071 EQUIP INTERIM RESULTS: A PHASE 1B STUDY EVALUATING ITOLIZUMAB IN SUBJECTS WITH MODERATE-TO-SEVERE UNCONTROLLED ASTHMA

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By R. Panettieri, New Brunswick, P. G. Bardin, P. Bremner
| Annals of Allergy, Asthma & Immunology Verified
CD6 is a co-stimulatory receptor predominantly expressed on T cells; its ligand, ALCAM, is expressed on antigen presenting, epithelial and endothelial cells. The CD6/ALCAM pathway is elevated in severe asthmatics and is implicated in Th2 and Th1/Th17 driven responses. Itolizumab is a humanized IgG1 monoclonal antibody that binds CD6 and blocks ALCAM interaction to inhibit T cell activation and trafficking.
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Abnormal vocal cord movement in patients with and without airway obstruction and asthma symptoms

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By K. Low, L. Ruane, N. Uddin, P. Finlay, K. K. Lau, K. Hamza, P. W. Holmes, G. Hamilton, P. G. Bardin
| Color Research & Application Verified
Abnormal vocal cord movements can cause laryngeal extrathoracic airway obstruction (often called vocal cord dysfunction – VCD) leading to asthma-like symptoms. These aberrant movements are characteristically present during inspiration and termed paradoxical vocal cord movement (PVCM). We have reported PVCM in up to 40% of severe asthmatics, but it is not known if PVCM is detectable in all patients with asthma-like symptoms and if the condition is more often associated with abnormal lung function.
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