P-M Bruch on Muck Rack

P-M Bruch

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Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target - Nature Communications

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By CL Tan, F. Czernilofsky, A. Cosma, E. Campo, S. Dietrich, L. Llaó-Cid, Y. Paul, M. Chazotte, K. Bestak, C. Schifflers, M. Iskar, T. Roider, P-M Bruch, JP Mallm, D. Colomer, D. Schapiro, EW Green, E. Moussay, J. Paggetti, M. Zapatka
| Nature Verified
Abstract T-cell exhaustion contributes to immunotherapy failure in chronic lymphocytic leukemia (CLL). Here, we analyze T cells from CLL patients’ blood, bone marrow, and lymph nodes, as well as from a CLL mouse model, using single-cell RNA sequencing, mass cytometry, and tissue imaging. T cells in CLL lymph nodes show the most distinct profiles, with accumulation of regulatory T cells and CD8+ T cells in various exhaustion states, including precursor (TPEX) and terminally exhausted (TEX) cells.
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