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P. Rod Dunbar on Muck Rack

P. Rod Dunbar

As seen in: Nature
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CXCR3 is associated with T-cell-induced heart damage in acute rheumatic fever

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By Francis M. Middleton, Reuben McGregor, Natalie Lorenz, Sarah Kilian, Anna Brooks, Timothy C. Barnett, Michael Serralha, William Martin, Glenn Pearson, Mark Mayo, David Broadhurst, Julie Bennett, Johann Brink, Nigel Wilson, Anna P. Ralph, Rachel Webb, Jonathan R Carapetis, Nicole J Moreland, Saem Mul Park, Ciara Ramiah, Judith Tresidder, Florina Chan Mow, P. Rod Dunbar
| Nature Verified
Abstract The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and prevent progressive heart damage. Here, participants with definite ARF were compared to other severe acute paediatric conditions and matched healthy controls by profiling circulating immune molecules and cells to inform disease mechanisms and potential druggable pathways.
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