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Pablo Barrias

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Articles

TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson’s disease

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By Pablo Ahumada-Montalva, Francisco Muñoz-Carvajal, Sara Bórquez-Macaya, Nohela Arévalo-Ramírez, Marisol Cisternas-Olmedo, Carolina Ortiz Jerez, Valentina Urbina-Muñoz, Wileidy Gómez, Pamela J. Urrutia, Etienne C. Hirsch, Manuel Ahumada, Pablo Barrias, Camila Muñoz-Yañez, Ariel Herrera-Vásquez, Gloria Arriagada, Ute Woehlbier, Melissa Calegaro-Nassif, Mario A Sanhueza, Rene L. Vidal, Diego Rojas-Rivera
| Nature Verified
Abstract The core pathological hallmark of Parkinson’s disease (PD) is the progressive degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc), driven by misfolding and aggregation of a-synuclein (aSyn) into Lewy bodies. This triggers severe cellular dysfunction, including endoplasmic reticulum (ER) stress and the dysregulation of the unfolded protein response (UPR). TMBIM6, an anti-apoptotic ER protein, inhibits the UPR sensor IRE1a.
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Cover Picture: Electron Spin‐Dependent Electrocatalysis for the Oxygen Reduction Reaction in a Chiro‐Self‐Assembled Iron Phthalocyanine Device

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By Laura Scarpetta-Pizo, Ricardo Venegas, Pablo Barrias, Karina Muñoz-Becerra
| Wiley Online Library Verified
Ana María Méndez-Torres Departamento de Ciencias del Ambiente, Departamento Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile, Av. Libertador Bernardo O'Higgins 3363, Estación Central, Santiago, Chile Search for more papers by this author
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Electron Spin‐Dependent Electrocatalysis for the Oxygen Reduction Reaction in a Chiro‐Self‐Assembled Iron Phthalocyanine Device

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By Laura Scarpetta-Pizo, Ricardo Venegas, Pablo Barrias, Karina Muñoz-Becerra
| pericles.pericles-prod.literatumonline.com
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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