Pablo Gomez Argudo

Abstract Collagen’s structural integrity and biological function derive from its characteristic triple helix, governed by a unique amino acid sequence containing the rare residue (2S,4R)-hydroxyproline (4R-Hyp). Substituting 4R-Hyp with its diastereomer 4S-Hyp markedly reduces triple-helix thermal stability and impairs collagen function. The origins of this destabilization have mostly been ascribed to stereoelectronic effects such as the gauche effect and n → π* interactions.

1 Introduction Significant potential lies in flexible and stretchable electronics with applications ranging from portable electronics over wearable devices on-skin electronics and neuroprosthetics to personalized healthcare.