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Pablo Soro-Barrio

As seen in: Nature, PLOS Biology
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Articles

Cell-specific bioorthogonal tagging of glycoproteins - Nature Communications

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By Keira E. Mahoney, Helen Flynn, Pablo Soro-Barrio, Acely Garza-Garcia, Aristotelis Antonopoulos, Tessa Keenan, Ambrosius P. Snijders, Mark Skehel, Svend Kjær, Martin A. Fascione, Carolyn R. Bertozzi, Stuart M. Haslam, Sabine Flitsch, Stacy A. Malaker, Ilaria Malanchi, Anna Cioce, Beatriz Calle, Fabio Parmeggian
| Nature Verified
Abstract Altered glycoprotein expression is an undisputed corollary of cancer development. Understanding these alterations is paramount but hampered by limitations underlying cellular model systems. For instance, the intricate interactions between tumour and host cannot be adequately recapitulated in monoculture of tumour-derived cell lines. More complex co-culture models usually rely on sorting procedures for proteome analyses and rarely capture the details of protein glycosylation.
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GREM1 is required to maintain cellular heterogeneity in pancreatic cancer - Nature

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By Linxiang Lan, May Zaw Thin, Jorge Almagro, Pablo Soro-Barrio, Axel Behrens
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDAC) shows pronounced epithelial and mesenchymal cancer cell populations1,2,3,4. Cellular heterogeneity in PDAC is an important feature in disease subtype specification3,4,5, but how distinct PDAC subpopulations interact, and the molecular mechanisms that underlie PDAC cell fate decisions, are incompletely understood. Here we identify the BMP inhibitor GREM16,7 as a key regulator of cellular heterogeneity in pancreatic cancer in human and mouse.
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Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak

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By Probir Chakravarty, Rebecca Jones, Kenzo Ivanovitch, Pablo Soro-Barrio
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article Kenzo Ivanovitch , Pablo Soro-Barrio, Probir Chakravarty, Rebecca A. Jones, Donald M. Bell, S. Neda Mousavy Gharavy, Despina Stamataki, Julien Delile, James C. Smith, James Briscoe Kenzo Ivanovitch, Pablo Soro-Barrio, Probir Chakravarty, Rebecca A. Jones, Donald M. Bell, S. Neda Mousavy Gharavy, Despina Stamataki, Julien Delile, James C. Smith, James Briscoe Published: May 17, 2021 https://doi.org/10.1371/journal.pbio.3001200 ?
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