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Paeton Wantuch

As seen in: BioRxiv, The Journal of Immunology
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Articles

Antibody responses in Klebsiella pneumoniae bloodstream infection: a cohort study

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By Wontae Hwang, Paeton Wantuch, Biana Bernshtein, Julia A Zhiteneva
| BioRxiv
Abstract Background: Klebsiella pneumonia (Kpn) is the fourth leading cause of infection-related deaths globally, yet little is known about human antibody responses to invasive Kpn. In this study, we sought to determine whether the O-specific polysaccharide (OPS) antigen, a vaccine candidate, is immunogenic in humans with Kpn bloodstream infection (BSI).
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A heptavalent O-antigen bioconjugate vaccine exhibits differential functional antibody responses against diverse Klebsiella pneumoniae isolates

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By Paeton Wantuch, Cory J Knoot, Lloyd S. Robinson, Evgeny Vinogradov
| BioRxiv
Abstract Klebsiella pneumoniae is a concerning pathogen that is now the leading cause of neonatal sepsis and is increasingly difficult to treat due to heightened antibiotic resistance. Thus, there is an urgent need for preventive and effective immunotherapies targeting K. pneumoniae. Vaccination represents a tractable approach to combat this resistant bacterium in some settings; however, there is currently not a licensed K. pneumoniae vaccine available. K.
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Adaptive humoral immune responses to type III capsular polysaccharide of Streptococcus pneumoniae.

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By Dustin Reed Middleton, Paeton Wantuch, Lina Sun, Fikri Y Avci
| The Journal of Immunology Verified
Capsular polysaccharides (CPSs) are important vaccine candidates given that they are located on the outermost surface of bacteria and have distinct structures. To induce CPS specific adaptive immune responses (i.e., T cell-mediated B cell responses), CPSs are conjugated with carrier proteins, to make glycoconjugate vaccines.
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