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Paige A. Barta

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High-throughput ligand diversification to discover chemical inducers of proximity - Nature Chemical Biology

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By James B. Shaum, Erica A. Steen, Daniela V. Wenge, Hakyung Cheong, Moritz Hunkeler, Eric M. Bilotta, Lauren Hargis, Timothy R. Bishop, Trever R. Carter, Matthias Hinterndorfer, Lucas Dada, Wen-Ji He, Fabian Offensperger, Hirotake Furihata, Charlie Hatton, Yanhe Wen, Benjamin Cravatt, Keary M. Engle, Katherine A. Donovan, Bruno Melillo, Seiya Kitamura, Alessio Ciulli, Scott Armstrong, Eric S. Fischer, Georg E. Winter, Michael Erb, Jordan Janowski, Zoe J. Rutter, Paige A. Barta, Abby M. Thornhill, Natalia Milosevich, Sydney R. Schweber
| Nature Verified
Abstract Chemical inducers of proximity (CIPs) stabilize biomolecular interactions, often causing an emergent rewiring of cellular biochemistry. While the discovery of heterobifunctional CIPs is expedited by rational design strategies, molecular glues have relied predominantly on serendipity. We hypothesized that preexisting ligands could be systematically decorated with chemical modifications to discover compounds that recruit proteins to a composite protein–ligand interface.
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