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Pall I. Olafsson on Muck Rack

Pall I. Olafsson

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Nanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in the human genome

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By Brynja Dogg Sigurpalsdottir, Guillaume Holley, Sverrir Þ. Sverrisson, Droplaug N. Magnusdottir, Ólafur þ. Magnússon, Gisli Masson, Olafur A. Stefansson, Bjarni V Halldorsson, Pall I. Olafsson, Arnaldur Gylfason
| Nature Verified
Abstract Aging is accompanied by widespread DNA methylation changes, yet their full genomic scope and parent-of-origin dynamics remain poorly understood. Here, we apply nanopore long-read sequencing to 7,284 whole blood samples enabling methylation measurements of 17,959,684 high-quality CpG units. Over 20% of the measured high quality CpG units undergo age-associated changes, predominantly hypomethylation.
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