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Articles

TNF-α/PAD4 axis drives hyperhomocysteine-induced white matter injury after acute ischemic stroke

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By Wei-hong Du, Hui Guo, Yi-Hui Wang, Xiao-yan Hu, Jia-Ning Zhang, Chun Yan Guo, Pan-pan Geng, Yu-ji Wang, Xin-chun Jin
| Nature Verified
Abstract Neural functional impairment following stroke is strongly linked to the loss of white matter (WM) integrity, a process critically dependent on the successful differentiation of oligodendrocyte precursor cells (OPCs). Given that hyperhomocysteine (HHcy) aggravates stroke prognosis, we hypothesized that it impairs OPCs differentiation during the recovery period.
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