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Pangfei Yang on Muck Rack

Pangfei Yang

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Articles

The epigenetic KMT5C-HDAC1 axis promotes hepatocellular carcinoma stemness and progression through SERPINA4 repression and chromatin compaction

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By Hongbin Huang, Caini Huang, Yang Liu Verified, Ruiyang Liu, Zhiju Zhao, Fei Xiao, Pangfei Yang, Shiping Xian
| Nature Verified
Abstract Epigenetic dysregulation is a hallmark of hepatocellular carcinoma (HCC), yet the mechanisms linking chromatin modifiers to tumor stemness remain incompletely understood. Here, we identify the histone methyltransferase KMT5C as master regulator of HCC stemness and progression through integrative analyses of patient-derived organoids, murine models, and clinical cohorts.
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