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Pannan Li on Muck Rack

Pannan Li

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Articles

Elevated ozone activates maternal immunity to drive offspring IgG-mediated anaphylaxis through IgG glycosylation alterations

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By Xiaoyun Wu, Zhihua Gong, Yuchai Tian, Xiaomin Liang, Huizhen Zhu, Jiyue Zhang, Yangcheng Hu, Xiaotong Ji, Huifeng Yue, Nan Sang, Mudan Wu, Pannan Li
| Nature Verified
Abstract Global allergic disease burden is rising, driven by environmental factors like ozone (O3)-induced oxidative stress. Epidemiological studies have linked prenatal oxidative stress to offspring allergy susceptibility, but causality remains unproven. Here, our retrospective analysis including 5,299 pregnancies postulates that mid-to-late gestational O3 exposure triggers maternal immune activation (MIA), increasing neutrophil/monocyte abnormality risks.
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