Paqui González Través on Muck Rack

Paqui González Través

As seen in: The Journal of Immunology
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Articles

The TAM receptors Axl and Mer play a joint-specific protective role in experimental arthritis

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By Paqui González Través, Anna Zagórska, Greg Lemke, Silke Beermann
| The Journal of Immunology Verified
Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an unrestrained inflammatory response in synovial joints. One family of tyrosine kinase receptors involved in anti-inflammatory feedback mechanism are Tyro3, Axl and Mer (TAM). The plasma level of the TAM receptor ligand Gas6 is significantly reduced in RA patients suggesting this feedback mechanism is impaired in RA. We investigated the individual role of each TAM receptor in experimental arthritis.
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