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Pär Norlund

As seen in: Nature
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Articles

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

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By Chong He, Jesse Meyer, Bhumil Patel, Jasinda H. Lee, Stephen Raj, Grace Keh, David Y. Fann, Carine Beaupere, Christine Robbins, Mário Vilela, Sebastian Troncoso, Jean-Philippe Pellois, Vyacheslav M. Labunskyy, Birgit Schilling, Yongliang Zhang, Nayana Prabhu, Jan Gruber, Michael Polymenis, Brian Kennedy, Shermaine Thein, Scott A. Hoose, Shivaanishaa Raventhiran, Sharah M. Capinpin, Matin Biekaran, Yelba E. Ortiz, Ruby A. Kaiser, Laura Caflisch, Helena M. Kondow- McConaghy, Scott K. Tsuchiyama, Pär Norlund
| Nature Verified
Abstract The FDA-approved fibrate, gemfibrozil, has been used clinically to treat hyperlipidaemia, showing efficacy both in lowering triglycerides and increasing high-density lipoproteins. However, in recent years, the drug has been increasingly investigated for potential clinical use in other diseases. Here, we show for the first time that gemfibrozil promotes healthy lifespan across multiple evolutionarily diverse species.
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