Parastesh Rezvanian

1 INTRODUCTION Multiple sclerosis (MS) is the most common non-traumatic cause of disability in young adults.1 Fulminant MS, also known as the malignant variant or Marburg's variant of MS (MVMS), was first described in 1906 and accounts for about 4% of MS cases.2 The disease is best recognized by its aggressive course, radiologic, and pathologic findings; it presents as a single plaque or multiple lesions, with considerable mass effect and cerebral edema on magnetic resonance imaging (MRI) and...