Paria Asadi Atoi on Muck Rack

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Strategies to Avoid Artifacts in Mass Spectrometry‐Based Epitranscriptome Analyses

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By Steffen Kaiser, Shane Byrne, Gregor Ammann, Paria Asadi Atoi
| Wiley Online Library Verified
Abstract For discovery of novel RNA modifications, a stringent workflow for structure validation is necessary to avoid misinterpretation of artifacts. The comparison of the synthetic standard to the native compound's retention time, full mass spectrum, high-resolution mass spectrum and metabolic isotope labeling allow for confident identification of RNA modifications.
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