Parthav Jailwala on Muck Rack

Parthav Jailwala

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Articles

Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progression

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By Lili Li, Taekyu Ha, Michael DiPrima, Dunrui Wang, Thomas Meyer, Justin B Lack, Hidetaka Ohnuki, Jing-Xin Feng, Parthav Jailwala, Giovanna Tosato
| Nature Verified
Abstract Despite therapeutic advances, metastatic colorectal cancer remains a therapeutic challenge as most patients will develop resistance to therapy and will progress. Epigenetic mechanisms are implicated in enabling the acquisition of new phenotypic traits as drivers of colorectal cancer progression, rather than new genetic mutations or expansion of existing mutant clones.
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