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Abstract Species B human adenoviruses (B-HAdVs), including HAdV7, HAdV3, and the re-emerging HAdV55, cause severe respiratory disease and engage desmoglein-2 (DSG2) through their fiber knob. Here, we report the identification and structural characterization of two monoclonal antibodies, 5C5 and 6G7, raised against the HAdV7 fiber knob. Both antibodies neutralize HAdV7 and display cross-reactivity toward other B-HAdVs, with nanomolar affinities.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
