André Lieber

Abstract G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development1,2, but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic3–6. Here we describe computational de novo design methods and a high-throughput “receptor diversion” microscopy-based screen for generating GPCR binding miniproteins with high affinity, potency and selectivity.

Open AccessArticle by Maximilian Richter , Hongjie Wang and André Lieber * Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA * Author to whom correspondence should be addressed.

Recorded on 25 May 2011 at Old Theatre, Old Building How can we make progress on climate change in the face of gridlock? Global Governance 2020 is a group of young academics, policymakers and business people from China, the United States and Europe. Robert Falkner is senior lecturer in international relations at LSE and a leading expert on global environmental politics. Anthony Giddens is former director of LSE and the author, most recently, of The Politics of Climate Change.