Pasi Nokelainen on Muck Rack

Pasi Nokelainen

South Carolina
As seen in: Wiley Online Library
#communications professional employed by @KaskasMedia #science #energy #circulareconomy #sustainability #ESG Sama suomeksi.
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Articles

Optimized Kappa‐Index Test Protocol to Detect Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis

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By Pasi Nokelainen, Mika Siuko, Joel Björklund, Outi Itkonen
| Wiley Online Library Verified
1 Introduction Immunoglobulin G (IgG) is synthesized intrathecally by B-cell–derived plasma cells in both infectious and immune-mediated central nervous system (CNS) inflammation [1]. The traditional method to detect intrathecal IgG synthesis, oligoclonal bands (OCB) by isoelectric focusing (IEF), is positive in 88%–95% of multiple sclerosis (MS) patients [2, 3] and it has been part of the 2017 McDonald criteria of MS diagnosis [4].
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