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Patho Vet AG

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Articles

Hypobaric hypoxia at 3,466 m suppresses hepatic bile acid metabolism and remodels the tumor lipidome in mice

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By Vetsuisse Faculty, Ain Shams, Patho Vet AG
| TechTrends
Background Systemic hypoxia induces whole-body metabolic adaptation, but its impact on tumor metabolism and hepatic bile acid (BA) pathways remains poorly defined. Methods We investigated how high-altitude (HA) hypobaric hypoxia at 3,466 m affects tumor growth, tumor lipid metabolism, and liver BA regulation in mice bearing LLC1 lung carcinoma or E0771 mammary carcinoma. Moreover, we tested the contribution of hypoxia/HIF signaling and HNF4A knockdown to BA-related gene regulation in HepG2 cells.
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