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Patricia Barnes

As seen in: BioRxiv
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Articles

Differential gene expression in cells with different p53 mutations identifies genome-wide p53 targets and shows distinct modulation of cellular pathways in response to DNA damage

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By Patricia Barnes, Bee Ling Ng, Hannes Ponstingl, Kioko Mwikali
| BioRxiv
Abstract The fundamental transcription factor p53 regulates cellular processes and integrates signals of cellular stress, triggering a coordinated response to ensure survival of cells restored to healthy function and programmed death of those that could not be repaired. Unsurprisingly, this is one of the most mutated genes in human cancers, with most changes occurring in the DNA-binding domain of the protein.
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