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Staphylococcus epidermidis alters macrophage polarization and phagocytic uptake by extracellular DNA release in vitro - npj Biofilms and Microbiomes
Abstract Biofilm formation shields Staphylococcus epidermidis from host defense mechanisms, contributing to chronic implant infections. Using wild-type S. epidermidis 1457, a PIA-negative mutant (1457-M10), and an eDNA-negative mutant (1457ΔatlE), this study examined the influence of biofilm matrix components on human monocyte-derived macrophage (hMDM) interactions.
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