Table of Contents Glucagon-like peptide-1 receptor agonist (GLP-1) drugs, such as semaglutide, have become well known for their ability to aid in weight loss. However, compounded versions of this drug have started to enter the market, which may pose risks to consumers, as they have not been reviewed by the U.S. Food and Drug Administration (FDA) for safety, effectiveness and quality. The only FDA-approved GLP-1 semaglutide medication for weight loss is Wegovy.