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Articles by Patrick Doyle
ILM at Meta Connect 2026
ILM Explores New Frontiers of Immersive Storytelling at Meta Connect 2026 By Patrick Doyle At Meta Connect 2026, Industrial Light & Magic announced Disney Immersive Cinema by ILM and National Geographic: Beyond, two new immersive experiences that explore how technology can expand the possibilities of storytelling.
A prospective pilot study of urine microRNA as a biomarker of urinary radiation toxicity following MRI-guided prostate stereotactic body radiotherapy
Abstract Introduction: Urinary toxicities are common following prostate radiotherapy and can impair quality of life. New biomarkers are needed that can predict the risk of urinary toxicity following MRI guided stereotactic body radiotherapy (MR-SBRT) to assist with selection of the most appropriate radiotherapy treatment approach. We aimed to identify urine miRNA biomarkers of radiation-induced urinary toxicities.
Arriva Orders Irizar Electric Buses for First Deployment in the Netherlands
panish bus maker Irizar will deliver its first electric vehicles to the Netherlands after securing an order from Arriva Personenvervoer Nederland for 39 battery-electric buses, the companies said. The order comprises 18 standard 12-metre units and 21 articulated 18-metre units of Irizar’s ie tram model.
MAN Delivers eTGX Electric Trucks to Koinè for Sanpellegrino Logistics in Italy
MAN Truck & Bus has delivered the first two units of its long-haul electric truck, the eTGX, to the Italian transport company Koinè. The battery-electric vehicles will be immediately integrated into the logistics operations of the beverage manufacturer Sanpellegrino, a brand owned by Nestlé Waters.
High‐Concentration Antibody Formulation via Solvent‐Based Dehydration
1 Introduction Therapeutic proteins such as monoclonal antibodies (mAbs), which are widely used to treat cancers, auto-immune diseases, and other chronic and acute illnesses, are typically administered through intravenous (IV) infusion.
Surface-Mediated Self-Assembly of Kinetoplast DNA: Depletion-Driven Dimer Formation and Quasi-2D Dynamics
Abstract Click to copy section linkSection link copied! Depletion interactions play a crucial role in the assembly and dynamics of colloidal systems in polymer-rich environments. In this study, we investigate the behavior of asymmetric, soft, colloidal kinetoplast DNA (kDNA) in the presence of linear polymers (linear DNA), focusing on their surface accumulation, orientation, diffusion, and dimer formation.
Data-driven organic solubility prediction at the limit of aleatoric uncertainty - Nature Communications
Abstract Small molecule solubility is a critically important property which affects the efficiency, environmental impact, and phase behavior of synthetic processes. Experimental determination of solubility is a time- and resource-intensive process and existing methods for in silico estimation of solubility are limited by their generality, speed, and accuracy.
Canada Gun Control
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Canada Gun Control
Gun control advocate and survivor of the 1989 Ecole Polytechnique massacre Nathalie Provost, right, speaks at a press conference on new measures to strengthen gun control as director of legal affairs at the National Association of Women and the Law, Suzanne Zaccour, listens in Ottawa, Ontario, on Thursday, Dec. 5, 2024.
Quantitative and spatially resolved detection of multiplexed microRNA from plant tissue via hybridization to hydrogel-bound DNA probes in nanoliter well arrays | Microsystems & Nanoengineering
Abstract Understanding complex regulatory networks in plant systems requires elucidating the roles of various gene regulators under a spatial landscape. MicroRNA are key regulators that impart high information value through their tissue specificity and stability when using expression patterns for evaluating network outcomes. However, current techniques that utilize spatial multiplexing and quantitation of microRNA are limited to primarily mammalian systems.
Shear annealing of a self-interacting sheet
Shear annealing of a self-interacting sheet 2D materials such as graphene, graphene oxide, transition metal dichalcogenides, and 2D polymers have unique properties which allow them to be used in many applications from electronics to energy to biotechnology. Producing and applying these materials often involves solution processing.
Dynamics of a self-interacting sheet in shear flow
Dynamics of a self-interacting sheet in shear flow Solution processing of 2D materials such as graphene is important for applications thereof, yet a complete fundamental understanding of how 2D materials behave dynamically in solution is lacking. Here, we extend previous work by Silmore et. al., Soft Matter, 2021, 17(18), 4707-4718 by adding short-ranged Lennard-Jones interactions to 2D sheets in shear flow.
Multifunctional zwitterionic hydrogels for the rapid elimination of organic and inorganic micropollutants from water - Nature Water
Abstract The elimination of micropollutants from water is challenging due to their chemical diversity, low concentrations and slow uptake by industrial adsorbents. Here we report a tunable multifunctional hydrogel platform for the rapid absorption of organic and inorganic micropollutants in a single step.
Tuning the topology of a two-dimensional catenated DNA network
Abstract Molecular topology of polymers plays a key role in determining their physical properties. We studied herein the topological effects on the static and dynamic properties of a 2D catenated network of DNA rings called a kinetoplast. Restriction enzymes that cleave DNA at sequence-specific sites are used to selectively cut and remove rings from the network and hence tune the molecular topology while maintaining overall structural integrity.
"Is DNA a Good Model Polymer?" by Douglas R. Tree, Abhiram Muralidhar et al.
Keywords Diffusion, Genetics, Hydrodynamics, Polymers, Transport properties Abstract The details surrounding the crossover from wormlike-specific to universal polymeric behavior has been the subject of debate and confusion even for the simple case of a dilute, unconfined wormlike chain.
"Revisiting Blob Theory for DNA Diffusivity in Slitlike Confinement" by Liang Dai, Douglas R. Tree et al.
Keywords blob theory, slit confinement, polymer diffusivity Abstract Blob theory has been widely applied to describe polymer conformations and dynamics in nanoconfinement. In slit confinement, blob theory predicts a scaling exponent of 2/3 for polymer diffusivity as a function of slit height, yet a large body of experimental studies using DNA produce a scaling exponent significantly less than 2/3.
Coarse-grained molecular dynamics simulations of immobilized micelle systems and their interactions with hydrophobic molecules
Coarse-grained molecular dynamics simulations of immobilized micelle systems and their interactions with hydrophobic molecules† Devashish Gokhale,a Ian Chenb and Patrick S. Doyle *ac Abstract Micelles immobilized in polymer materials are of emerging interest in drug delivery, water treatment and other applications. Immobilization removes the need for membrane-based separation to eliminate micelles from the medium, enabling facile extraction and delivery in diverse industries.
Ionic Effects on the Equilibrium Conformation of Catenated DNA Networks
Download Hi-Res ImageDownload to MS-PowerPointCite This:Macromolecules 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Beatrice W. Soh, Ahmed Khorshid Ahmed Khorshid Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States , Dana Al Sulaiman Dana Al Sulaiman Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States , and Patrick S.
Topological Simplification of Complex Knots Untied in Elongational Flows
Download Hi-Res ImageDownload to MS-PowerPointCite This:Macromolecules 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Beatrice W. Soh, Alexander R. Klotz Alexander R. Klotz Department of Physics and Astronomy, California State University, Long Beach, California 90840, United States , and Patrick S. Doyle* LEARN ABOUT THESE METRICS Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals.
A Platform for Multiplexed Colorimetric microRNA Detection using Shape-encoded Hydrogel Particles
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Complex DNA knots detected with a nanopore sensor
Abstract Equilibrium knots are common in biological polymers—their prevalence, size distribution, structure, and dynamics have been extensively studied, with implications to fundamental biological processes and DNA sequencing technologies. Nanopore microscopy is a high-throughput single-molecule technique capable of detecting the shape of biopolymers, including DNA knots.
Effects of Side Chains on Polymer Knots
Knotting is a common phenomenon that occurs in a wide range of linear objects, including headphone cords, DNA,(1,2) proteins,(3−7) and other molecules.(8,9) Recent studies have revealed that knotting can significantly affect polymer behavior, such as reducing mechanical strength of polymers,(10) slowing down polymer dynamics,(11,12) jamming nanopore translocation(13) and DNA ejection from virial capsids,(14−17) and facilitating catalysis of proteins.(5) To understand the general behavior of...
Untying of Complex Knots on Stretched Polymers in Elongational Fields
The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.macromol.8b01879. Detailed experimental method, simulation movies details, schematics of simulated knot types, individual simulation trajectories in elongational fields and at constant tension, further analysis of Δrmax, distribution of untying times and calculation of confidence intervals (PDF) Simulation movies (ZIP)
Universal Knot Spectra for Confined Polymers
Knotting is a prevalent phenomenon which occurs at the macroscale (e.g., in headphone cords) and at the microscale (e.g., in DNA and proteins). For a confined polymer, the knotting probability can rapidly approach 100% as the degree of confinement increases, while the mechanism of knot formation in a confined space is unclear.
Microparticle Parking and Isolation for Highly Sensitive MicroRNA Detection
Isolating small objects, such as particles, cells, and molecules, in individual aqueous droplets is useful for chemical and biological assays. We have developed a simple microfluidic platform to immobilize (park) microparticles at defined locations, and isolate particles in monodisperse droplets surrounded by immiscible oil.
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