Patrick E. Rothwell
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Articles by Patrick E. Rothwell
NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration
Abstract Schizophrenia, a serious mental illness, is associated with evidence of NMDA receptor (NMDAR) dysfunction and characterized by cognitive impairments that reflect impaired value updating and feedback-driven control. However, the cellular and circuit-level mechanisms underlying these disruptions remain unclear.
Biblis to Become Laser Fusion Hub
Computer animation of the world's first laser fusion power plant in Biblis; Image: Focused EnergyImage: Focused Energy Focused Energy advances plan to build the world’s first commercial laser fusion power plant at the former Biblis nuclear power station BIBLIS / DARMSTADT, HESSEN, GERMANY, July 30, 2026 / EINPresswire.com/ -- Germany’s Federal Ministry of Research, Technology and Space has selected Biblis to become the home of the national laser fusion hub as part of the “Fusion 2040” program...
Synaptic dysfunction and adaptation after NMDA receptor ablation in the mouse medial prefrontal cortex
Abstract N-methyl-D-aspartate receptors (NMDARs) in the prefrontal cortex (PFC) are critical regulators of neuronal excitability, synaptic plasticity, and cognitive function. NMDAR disruptions, including pharmacological blockade and anti-NMDAR encephalitis, can mimic symptoms of schizophrenia. These observations support the glutamate hypothesis of schizophrenia, which posits that symptoms arise from abnormal corticolimbic glutamatergic signaling.
Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling - Communications Biology
Abstract Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met-enkephalin-Arg-Phe (MERF). Enkephalins are short-lived, endogenous opioid peptides that mediate the body’s intrinsic analgesic response.
Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind - Nature Neuroscience
Abstract Nucleus accumbens dopamine signaling is an important neural substrate for decision-making. Dominant theories generally discretize and homogenize decision-making, when it is in fact a continuous process, with evaluation and re-evaluation components that extend beyond simple outcome prediction into consideration of past and future value.
Exploiting the Angiotensin-Converting Enzyme Pathway to Augment Endogenous Opioid Signaling
Abstract Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met-enkephalin-Arg-Phe (MERF). Enkephalins are short-lived, endogenous opioid peptides that mediate the body's intrinsic analgesic response.
Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind
Abstract Nucleus accumbens dopamine signaling is an important neural substrate for decision-making. Dominant theories generally discretize and homogenize decision-making, when it is in fact a continuous process, with evaluation and re-evaluation components that extend beyond simple outcome prediction into consideration of past and future value.
Sex Differences in Morphine Sensitivity of Neuroligin-3 Knockout Mice
Abstract Sex has a strong influence on the prevalence and course of brain conditions, including autism spectrum disorders. The mechanistic basis for these sex differences remains poorly understood, due in part to historical bias in biomedical research favoring analysis of male subjects, and the exclusion of female subjects.
Weekly Update for Government Contractors and Commercial Businesses – September 2023 #3 | JD Supra
Upcoming Events: Register to attend PilieroMazza’s upcoming events here. Recent Thought Leadership: Check out PilieroMazza’s recent client alerts and blogs here. Podcasts: Listen to PilieroMazza’s podcasts GovCon Live! here and Clocking in with PilieroMazza here. GOVERNMENT CONTRACTS Reducing the Negative Impacts of a Government Shutdown for Federal Contractors, PilieroMazza Client Alert, Jon Williams, Nichole D. Atallah, Patrick T.
Reducing the Negative Impacts of a Government Shutdown for Federal Contractors | JD Supra
Once again, the specter of a government shutdown looms over the federal contracting community. The federal government is set to run out of funding on September 30 and tensions in the House are making it ever more likely that a shutdown will occur. Below are key steps your business should take to mitigate the possible negative impact of a government shutdown, along with shutdown-related labor and employment considerations for government contractors. A.
Weekly Update for Government Contractors and Commercial Businesses – July 2023 #3 | JD Supra
GOVERNMENT CONTRACTS Federal Court Prohibits SBA’s Use of Rebuttable Presumption for 8(a) Program, PilieroMazza Client Alert, Antonio R. Franco and Patrick T.
Federal Court Prohibits SBA’s Use of Rebuttable Presumption for 8(a) Program | JD Supra
On July 19, 2023, the U.S. District Court for the Eastern District of Tennessee issued an important decision where it declared that the Small Business Administration’s (SBA) rebuttable presumption of social disadvantage, which is used in admitting many small-disadvantaged businesses to the SBA’s 8(a) program, violated the equal protection rights of a government contractor and enjoined the use of the rebuttable presumption in administering the 8(a) program. Ultima Servs. Corp. v.
5 Key Ways a Contractor Can Be Subject to a Government Claim | JD Supra
The performance of any government contract by a contractor has the potential to bring certain monetary risks of a government claim against the contractor. Below, we discuss 5 key ways a government contractor can be subject to a government claim and best practices to reduce your risks. 1. Overpayment A common type of government claim is based upon what the government considers to be an overpayment on its part.
SBA Increases Its Size Standards, Opening More Opportunities for Winning Government Contracts | JD Supra
The long-awaited increase to size standards by the Small Business Administration (SBA) has arrived. On March 31, 2022, SBA issued four final rules that increase the small business size standards for a number of industries. As a result, many businesses will gain eligibility for federal small business assistance programs or retain eligibility for a longer period.
μ-Opioid Receptor (Oprm1) Copy Number Influences Nucleus Accumbens Microcircuitry and Reciprocal Social Behaviors
Assays of social behavior To evaluate social behavior, we used a battery of previously described assays: social CPP (Panksepp and Lahvis, 2007; Cinque et al., 2012; Dölen et al., 2013); the standard three-chamber test of sociability and preference for social novelty (Nadler et al., 2004); reciprocal social interaction (Terranova and Laviola, 2005); and a real-time preference test for social interaction (Shah et al., 2013).
Mu Opioid Receptor (Oprm1) Copy Number Influences Nucleus Accumbens Microcircuitry and Reciprocal Social Behaviors
Research Articles, Systems/Circuits Carlee Toddes, Emilia M. Lefevre, Dieter D. Brandner, Lauryn Zugschwert and Patrick E. Rothwell Journal of Neuroscience 22 July 2021, JN-RM-2440-20; DOI: https://doi.org/10.1523/JNEUROSCI.2440-20.2021 Abstract The mu opioid receptor regulates reward derived from both drug use and natural experiences, including social interaction, through actions in the nucleus accumbens.
Raytheon Challenges CO Intellectual Property Decision in COFC | JD Supra
In a recent Court of Federal Claims (COFC) case,[1] Raytheon Corporation (Raytheon) challenged a federal agency order that a Government Purpose Right (GPR) legend be affixed to documents purportedly containing technical data.
Weekly Update Newsletter - September 2019 #4 | JD Supra
FALSE CLAIMS ACT Small Businesses and the False Claims Act (FCA): Are More FCA Cases Against Small Businesses on the Horizon? September 19, 2019, Timothy Valley On August 20, 2019, the U.S. Department of Justice (DOJ) announced that it had reached a $20 million settlement with Luke Hillier (Hillier), the majority owner and former CEO of a Virginia-based defense contractor, ADS, Inc.
Protégé Subcontract Revenues from Mentor Hold No Basis for Economic Dependence | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
GAO Finds That Federal Agencies Have Made Few SBIR Awards to Small Businesses Majority-Owned by Multiple Venture Capital Operating Companies, Hedge Funds, or Private Equity Firms | PilieroMazza PLLC - JDSupra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
GAO Sustains Protest Alleging Misrepresentation in Proposal Regarding Availability of Incumbent Staff | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Breach of Settlement Agreement Suits Against Federal Government Not Precluded by Finality Clauses | JD Supra
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New and Proposed Certified Cost or Pricing Data Requirements Will Shift Burdens upon DoD Contractors | JD Supra
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Weekly Update Newsletter - July 2018 | JD Supra
JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations. This Privacy Policy describes how JD Supra, LLC ("JD Supra" or "we," "us," or "our") collects, uses and shares personal data collected from visitors to our website (located at www.jdsupra.com) (our "Website") who view only publicly-available content as well as subscribers to our services (such as our email digests or author tools)(our "Services").
Weekly Update Newsletter - April 2018 #3 | JD Supra
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An Instructive Warning to Contractors of the Need to Understand CDA Requirements | JD Supra
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GSA & OMB are Holding a Public Meeting and Requesting Written Comments Regarding Implementation of the “Amazon Amendment”
The General Services Administration (“GSA”) and the Office of Management and Budget (“OMB”) are providing an important opportunity to the public to provide input into the implementation of the so-called “Amazon Amendment,” Section 846 of the recently-enacted National Defense Authorization Act (“NDAA”) for Fiscal Year 2018. GSA has published in the Federal Register a Notice of public meeting and request for information (“Notice”) which can be found here.
SBA Office of Hearings and Appeals Reaffirms "Unconditional Ownership" Requirement in the SBA SDVOSB Program
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House Small Business Committee Approves Legislation Providing For Expedited Partial Payments of Requests for Equitable Adjustment to Small Construction Contractors | PilieroMazza PLLC - JDSupra
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New Option for Past Performance Ratings - Set-Aside Alert
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Autism’s hidden habit
Shane Stoner’s addiction began in 2008. He lost a factory job, his parents divorced, his father died — and then a relative introduced him to heroin. “I felt like heroin gave me confidence,” Stoner says. “I could get out of bed in the morning and do the day. No matter what happened, it made me feel like it was going to be all right.” It erased his constant anxiety. Stoner, now 44, eventually entered detox in 2013 after he was arrested for stealing copper from an abandoned house.
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