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Prakashkumar Dobariya on Muck Rack

Prakashkumar Dobariya

As seen in: MDPI, ACS Publications, BioRxiv
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Articles

Intranasal Delivery of Metabolically Resilient Glutathione: In Vivo Pharmacokinetic, Permeation, and Efficacy Studies

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By Kiran D. Bhilare, Prakashkumar Dobariya, Antonio Lee, Wei Xie
| dx.doi.org
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Intranasal Delivery of Metabolically Resilient Glutathione: In Vivo Pharmacokinetic, Permeation, and Efficacy Studies

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By Kiran D. Bhilare, Prakashkumar Dobariya, Antonio Lee, Wei Xie
| ACS Publications
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Exploiting the Angiotensin-Converting Enzyme Pathway to Augment Endogenous Opioid Signaling

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By Prakashkumar Dobariya, Jessica Williams, Filip Hanák, Patrick E. Rothwell
| BioRxiv
Abstract Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met-enkephalin-Arg-Phe (MERF). Enkephalins are short-lived, endogenous opioid peptides that mediate the body's intrinsic analgesic response.
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