Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Patrick Eiring
Expansion Microscopy Reveals the Spatial Association of Therapeutic Antibody–Receptor Complexes With Cholesterol-Rich Membrane Domains
1 Introduction The cell membrane, a barrier that separates its internal environment from the outside, is more than a passive barrier, but a dynamic mosaic of lipids and proteins that coordinate cell signaling [1, 2]. While early models like the Singer–Nicolson fluid mosaic model described membranes as homogenous lipid bilayer with proteins freely diffusing [3], subsequent discoveries revealed that lipids are not uniformly distributed in the membrane.
Expansion Microscopy Reveals the Spatial Association of Therapeutic Antibody–Receptor Complexes With Cholesterol-Rich Membrane Domains
1 Introduction The cell membrane, a barrier that separates its internal environment from the outside, is more than a passive barrier, but a dynamic mosaic of lipids and proteins that coordinate cell signaling [1, 2]. While early models like the Singer–Nicolson fluid mosaic model described membranes as homogenous lipid bilayer with proteins freely diffusing [3], subsequent discoveries revealed that lipids are not uniformly distributed in the membrane.
Loss of GPRC5D enhances the proliferative capacity and competitive fitness of myeloma upon anti-GPRC5D immunotherapy
|
Abstract Immunotherapies targeting surface antigens have transformed the treatment landscape of multiple myeloma (MM), with GPRC5D emerging as a promising therapeutic target. Monoallelic loss of GPRC5D is frequently observed in newly diagnosed MM patients, and the incidence of acquired GPRC5D alterations increases following exposure to GPRC5D-directed therapies.
By Umair Munawar, Thomas Nerreter, Alexander M. Leipold, Seungbin Han, Christina Verbruggen, Elena Gerhard-Hartmann, Cornelia Vogt, Sabine Roth, Julia Weingart, Patrick Eiring, Marietta Truger, Nazia Afrin, Torsten Steinbrunn, Xiang Zhou, Johanna Lehmann, Max Koppel, Andreas Rosenwald, Claudia Haferlach, Michael Hudecek, Antoine-Emmanuel Saliba, Leo Rasche, Markus Sauer, Hermann Einsele, Bernhard Kuster, Johannes M. Waldschmidt, K. Martin Kortüm, Johanna Thurner, Silvia Nerreter, Björn Grams, Shilpa Kurian, Emma Besant, Yoko Tamamushi, Nina Rein
|
Nature
Verified
Single-molecule localization microscopy reveals the molecular organization of endogenous membrane receptors
Abstract Super-resolution microscopy in combination with genetic labeling methods allows imaging of single proteins in cells. However, visualizing endogenous proteins on primary cells remains challenging due to the use of sterically demanding antibodies for labeling. Here, we demonstrate how immunolabeling conditions and antibody cross-linking influence the quantification and identification of membrane receptor stoichiometry on cells using single-molecule localization microscopy.
Functionalized Docetaxel Probes for Refined Visualization of Mitotic Spindles by Expansion Microscopy
Introduction Click to copy section linkSection link copied! Mitosis is a fundamental process of cell division that is responsible for the accurate segregation of the duplicated genome into two daughter cells. In this process, the mitotic spindle, a highly intricate structure composed of microtubules, motor proteins and numerous other associated proteins, generates the forces required for the separation of sister chromatids between the two daughter cells.
Functionalized Docetaxel Probes for Refined Visualization of Mitotic Spindles by Expansion Microscopy
Journal of the American Chemical Society Cite this: J. Am. Chem. Soc. 2025, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.
Correction: Brosch et al. Glucose and Inositol Transporters, SLC5A1 and SLC5A3, in Glioblastoma Cell Migration. Cancers 2022, 14, 5794
Open AccessCorrection by 1,†, 1,2,†, 1, 1, 3, 1, 2, 2,4,5, 1, 6, 7, 1,*,‡ and 1,*,‡ 1 Department of Biotechnology & Biophysics, Biocenter, University of Würzburg, 97074 Würzburg, Germany 2 Fraunhofer Institute for Biomedical Engineering (IBMT), 66280 Sulzbach, Germany 3 Julius-von-Sachs Institute, University of Würzburg, 97082 Würzburg, Germany 4 Department of Molecular and Cellular Biotechnology, Saarland University, 66123 Saarbrücken, Germany 5 Faculty of Marine Science, Universidad...
Back Cover: Coronaviruses Use ACE2 Monomers as Entry‐Receptors (Angew. Chem. Int. Ed. 30/2023)
Graphical Abstract A coronavirus (round particles) carrying trimeric spike proteins infects a host cell that expresses monomeric ACE2 receptors. The low density of ACE2 receptors on the cell membrane demonstrates that on average only one spike protein per virus particle can bind to an ACE2 receptor simultaneously, which provides SARS-COV-2 a high infectivity. After binding, the membranes fuse and viral components are released into the cell, as reported by Gerti Beliu, Markus Sauer et al.
Coronaviruses Use ACE2 Monomers as Entry‐Receptors
Graphical Abstract dSTORM imaging shows that the entry-receptor ACE2 of coronaviruses is homogeneously distributed in the plasma membrane of host cells with expression levels of only 1–2 ACE2 molecules μm−2. In contrast to previous reports that suggested binding of multiple spikes per virus to ACE2 homodimers or oligomers our data reveal that ACE2 is expressed as monomer in the plasma membrane in the absence and presence of trimeric spike proteins.
Coronaviruses use ACE2 monomers as entry receptors
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
Targetable Conformationally Restricted Cyanines Enable Photon‐Count‐Limited Applications**
Abstract Modern fluorescence-based methods put intense demands on probe molecules. Here we report conformationally restrained cyanines suitable for biomolecule labeling. These efforts establish contexts in which reduced cyanine isomerization leads to a significant enhance in photon output. Abstract Cyanine dyes are exceptionally useful probes for a range of fluorescence-based applications, but their photon output can be limited by trans-to-cis photoisomerization.
Improved biocatalytic cascade conversion of CO2 to methanol by enzymes Co-immobilized in tailored siliceous mesostructured cellular foams
Improved biocatalytic cascade conversion of CO2 to methanol by enzymes Co-immobilized in tailored siliceous mesostructured cellular foams† Milene Zezzi do Valle Gomes, ‡*a Gerard Masdeu, ‡b Patrick Eiring,c Alexander Kuhlemann,c Markus Sauer,c Björn Åkermanb and Anders E. C.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Patrick
Contact Patrick, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack