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Articles by Patrick Leung
Gut microbiome of children with Autism Spectrum Disorder associates with clinical severity
Abstract Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition. Although the gut microbiome has been implicated in ASD, prior studies have insufficiently addressed clinical heterogeneity. Here, we perform shotgun metagenomic sequencing on stool samples from 720 children with ASD (median age 8 years, 87% male) and 151 matched controls.
Su1290 GUT MICROBIOME-MEDIATED HOST EPIGENETIC REGULATION INFLUENCES INFANTS’ NEURODEVELOPMENTAL OUTCOMES
Also available on ScienceDirect
Epigenome-microbiome interplay in early life associates with infants’ neurodevelopmental outcomes
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Keywords birth cohort microbiome DNA methylome vertical transmission neurodevelopment ASD ADHD Caesarean section DOHaD multi-omics Introduction The prenatal and early postnatal periods are critical periods for immune development orchestrated by an intricate interplay between host and environmental factors.1,2,3 Recent data suggest that epigenetic programming of gene expression profiles is sensitive to the early-life environment and can impact health outcomes in children.4,5,6 Unlike the human...
By Siew Chien Ng, Ye Peng, Lin Zhang, Shilin Zhao, Oscar Wong, Xin A. Liu, Hang Li, Jie Zhu, Yingzhi Liu, Qi Su, Tak Yeung Leung, Sandra S. M. Chan, Patrick Leung, Jessica Ching, Xi Zhang, Xueqi Wu, Yuzhou Chen, Shuai Yan, Whitney Tang, Ting Fan Leung, Hein Min Tun, Pui-Kuan Cheong, Long Ip, Chun Pun Cheung
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Cell Press
Verified
Ciao Ufo
Regia di Patrick Leung. Un film con Tien You Chui, Charlene Choi, You-Nam Wong, Michelle Wai, Siu Hin Ng. Cast completo Genere Commedia, Drammatico, Fantascienza - Hong Kong, 2019, durata 122 minuti. Condividi VOTA 1 SCRIVI Aggiungi Ciao Ufo tra i tuoi film preferiti Riceverai un avviso quando il film sarà disponibile nella tua città, disponibile in Streaming e Dvd oppure trasmesso in TV. Accedi o registrati per aggiungere il film tra i tuoi preferiti.
Distinct diet-microbiome associations in autism spectrum disorder - Nature Communications
Abstract Autism spectrum disorder (ASD) is linked to both altered gut microbiota and unhealthy diets; however, the mechanistic connections remain elusive. In this study, we conducted a systematic analysis of fecal microbiome metagenomic data, paired with granular dietary assessments and phenotypic profiles, across a cohort of 818 children (462 with ASD, 356 without ASD; mean age = 8.4 years; 27.3% female).
Demystifying quantum: The very small world behaves strangely
Patrick Leung · Follow 4 min read · -- Quantum computing has become a buzzword in venture investment circles and a national strategy priority worldwide. Yet the term “quantum” often feels intimidating at first glance — and rightly so. It pictures a realm so counterintuitive that reconciling it with our everyday experience is genuinely challenging.
Impact of COVID-19 on Afterschool Programming Outcomes: Lasting Implications for Underserved Early Adolescents
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A 12-Year Review of Upper Extremity Deep Vein Thrombosis-Are They the Same as Lower Extremity Deep Vein Thrombosis?
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
China Media and Entertainment Weekly News Bulletin - ISSUE 15 Week of 9 September 2024
13/09/2024 (1) Action star Donnie Yen Receives World Outstanding Chinese Award Hong Kong action star Donnie Yen was awarded the World Outstanding Chinese Award for his film contributions.
China Media and Entertainment Weekly News Bulletin - ISSUE 14 Week of 2 September 2024
06/09/2024 (1) Coldplay to Perform at Hong Kong’s Soon-to-Open Mega Stadium Early Next Year Coldplay will perform at Hong Kong’s new 50,000-seat mega stadium in Kai Tak Sports Park early next year, marking one of the venue’s first major events as it is set to open in early 2025. (2) Luxury Fashion House Balenciaga Launches Exclusive Sneaker On JD.com Balenciaga launched its flagship store on JD.com, joining other Kering brands to access the platform’s 600 million customers.
China Media and Entertainment Weekly News Bulletin - ISSUE 9 Week of 29 July 2024
02/08/2024 (1) Alibaba’s Taobao, ByteDance’s Douyin Seek E-Commerce Price War Detente with New Policies Alibaba and Douyin are shifting away from a sole focus on low pricing strategies towards a more sustainable approach. (2) Tech War: China Narrows AI Gap with US Despite Chip Restrictions Chinese tech companies are rapidly advancing domestic AI capabilities amidst chip supply restrictions.
China Media and Entertainment Weekly News Bulletin - Issue 1 (Week of 3 June 2024)
We’d like to introduce you to our latest newsletter. Called China Media and Entertainment News and published weekly, it provides a quick, easy to read, overview of the media and entertainment scene to keep you up to date with the essentials. In this issue we look at: (1) New Regulations for Micro-dramas Come Into Effect New regulations for managing micro-dramas came into effect on 1st June, which now mean unreviewed and unfiled micro-dramas cannot be shared online.
Primary biliary cholangitis: molecular pathogenesis perspectives and therapeutic potential of natural products
Yanling Zhao1*, Shizhang Wei2, Lisheng Chen1,3, Xuelin Zhou4 and Xiao Ma3 1Department of Pharmacy, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China 2Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University, Beijing, China 3College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China 4Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China Primary...
Plasma lipidomics of primary biliary cholangitis and its comparison with Sjögren’s syndrome
Introduction Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease characterized by the progressive destruction of intrahepatic bile duct epithelial cells (1). PBC mainly occurs in middle-aged women over 40 years old, with an estimated global prevalence of 146 per million (2). Most patients are asymptomatic in the early stage of PBC, whereas some commonly present with fatigue and pruritus (3).
Breastfeeding and Active Bonding Protects against Children’s Internalizing Behavior Problems
Breastfeeding is associated with numerous health benefits to offspring and mothers and may improve maternal-infant bonding. Ample evidence suggests breastfeeding can improve child neurodevelopment, but more research is needed to establish whether breastfeeding is linked to the development of child psychopathology. This paper aims to explore the effects of both breastfeeding and mother-child interactions on child behavioral outcomes at a later age.
Family-based association study of DRD4 gene in methylphenidate-responded Attention Deficit/Hyperactivity Disorder
The 48-basepair (48-bp) variable number tandem repeat (VNTR) polymorphism in exon 3 of the dopamine receptor D4 gene (DRD4) is implicated in the etiology of attention-deficit/ hyperactivity disorder (ADHD). In particular, ADHD in European-ancestry population is associated with an increased prevalence of the 7-repeat (7R) allele of the exon 3 VNTR. However, it is intriguing to note that the 7R allele has been found to be of very low prevalence in the Chinese general population.
Chronic Interferon-gamma expression triggers a female bias in the development of primary biliary cholangitis
An important issue in autoimmunity research has been the ability to identify the mechanisms that link genetic susceptibility to environmental influences. In most autoimmune diseases, including primary biliary cholangitis (PBC), the serologic hallmarks of disease precede clinical pathology by years, thus making early diagnosis and potential treatment difficult if not unlikely.
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