Patrick Li on Muck Rack

Patrick Li

Verified
United States
As seen in: T: The New York Times Style Magazine, Medium, The New York Times, Nature, Wiley Online Library, JAMA (The Journal of the American Medical Association), Royal Society of Chemistry, Packt Hub, The Journal of Immunology, TFE Times, Blockchain in Healthcare Today and
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Articles

Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells

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By Friedrich Fauser, Sebastian Arangundy-Franklin, Jessica Davis, Lifeng Liu, Nicola Schmidt, Luis Rodriguez, Luis Rodríguez, Danny F. Xia, Nga Nguyen, Nicholas A. Scarlott, Lynn Truong, Satria Sajuthi, Sarah Hinkley, Bhakti Kadam, Stephen Lam, Bryan Bourgeois, Emily Tait, Mohammad Qasim, Adeline Chen Verified, Andrew Nguyen, Patrick Li Verified, Gregory Davis, Jeffrey Miller, Rakshaa Mureli, Irene S. Tan, Vishvesha Vaidya, Yuri R. Bendaña, David A. Shivak, Andreas Reik, David E. Paschon
| Nature Verified
Abstract Serine integrases can precisely integrate large DNA constructs into desired chromosomal sites but only if their natural target site is first installed into the recipient genome. Here, to retarget serine integrases to a desired genomic site, we develop a modular integrase (MINT) system for genome editing. Through a combination of structural modeling, single-round directed evolution and screening in human cells, we retargeted the specificity of the serine integrase Bxb1.
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SPILL ALBUM REVIEW: CABARET VOLTAIRE – BUT WHAT TIME IS IT REALLY?

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By Patrick Li Verified
| Spill Magazine
Cabaret Voltaire, initially consisting of Richard Kirk, Chris Watson, and Stephen Mallinder, is an English techno music group that experienced a degree of success with their song “Sensoria” in 1984, which was a perfect anthem to hear during the burgeoning underground dance movement of the 80’s. With the revival of interest in all things 80’s, Kirk, now the sole member of the band, was given an offer by the Coachella Festival in 2017 to reunite the band but decided against it.
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Quantification of cell‐type‐specific plasmodesmata distribution in Arabidopsis roots reveals spatial and patterning dynamics

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By Gwendolyn Davis, Patrick Li Verified, Jan J. Pavlou
| Wiley Online Library Verified
INTRODUCTION Cell to cell communication is crucial to multicellularity and plays a key role in cellular patterning and sustaining organ function. Plant cells communicate through a variety of pathways including the extracellular apoplastic pathway, via membrane-spanning transporters, and directly through cytoplasmic channels called plasmodesmata which form the symplastic pathway (Sager & Lee, 2014).
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