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Patrick Metang

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Articles

Silencing lipid catabolism determines longevity in response to fasting

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By Lexus Tatge, Juhee Kim, Rene Solano Fonseca, Kyle Feola, Ann Johnson, Kielen R. Zuurbier, Victor Lopez, Anthony Daley, Emma Werner, Abigail Watterson, Jeffrey McDonald, Vincent Tagliabracci, Michael French, Peter Douglas, Jordan M. Wall, Gupse Otuzoglu, Jaeyoung Oh, Shaghayegh T. Beheshti, Patrick Metang, Sonja L. B. Arneaud
| Nature Verified
Abstract Oscillations between lipid anabolism and catabolism are essential for maintaining cellular health during metabolic fluctuations. Fasting, a conserved determinant of aging, improves disease outcomes and extends lifespan, yet the relative contributions of lipid catabolism versus its attenuation to fasting-induced longevity remain unresolved. The metabolic flexibility of C. elegans under variable nutrient availability provides a powerful system to address this question.
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