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Obesity is an established risk factor for numerous diseases, including metabolic and cardiovascular disorders, as well as certain cancers.1,2 Most of this evidence is derived from anthropometric data collected once, typically in middle to late adulthood.
Dog ownership has been associated with several complex traits and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through meta-analysis of 31,566 Swedish twins in five discovery cohorts and additional 65,986 European-ancestry individuals in three replication cohorts from Sweden, Norway, and the UK.
Special Issue Published as part of the Environmental Science & Technology virtual special issue “The Exposome and Human Health”. Neurodegeneration and neurodegenerative aggregation diseases are globally on the rise. Increasing prevalence of Alzheimer’s disease (AD), Parkinson’s disease (PD) and peripheral neuropathies concerns industrial as well as developing countries.
Abstract Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels. We identify rare exonic variants in DUSP1, NOTCH4, and SLC9A4 to be associated with eczema.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
