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Paul M. Coen on Muck Rack

Paul M. Coen

Orlando
As seen in: Nature, Wiley Online Library, Medscape, Science Magazine, BioRxiv, Stem Cell Reports, medRxiv
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Articles

12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII - Nature Communications

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By Jazmin Calyeca, Hsiang-Ling Huang, Pablo Vidal, Diego Hernandez-Saavedra, Juan J. Aristizabal-Henao, Laurie J. Goodyear, Paul M. Coen, Loren E Wold, Ana Mora
| Nature Verified
Abstract Aging poses significant challenges to cardiovascular health necessitating novel therapeutic approaches. This study investigates the potential of the brown adipose tissue (BAT) derived lipokine 12,13-diHOME to mitigate age-induced impairments in cardiovascular function. Analysis of human and rodent plasma signaling lipids reveals a decline in 12,13-diHOME levels with age.
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Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model

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By Maddalena Parafati, Zon Thwin, Legrand K Malany, Paul M. Coen, Siobhan Malany
| Stem Cell Reports Verified
ArticleOnline now102550Open access 1Department of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA 2Micro-gRx, INC, Orlando, FL 32827, USA 3Translational Research Institute, AdventHealth, Orlando, FL 32804, USA Publication History: Received December 17, 2024; Revised May 28, 2025; Accepted June 2, 2025; Published online June 26, 2025 DOI: 10.1016/j.stemcr.2025.102550 External LinkAlso available on ScienceDirect External Link Copyright:...
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Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults

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By Emma L. Gay, Caterina Rosano, Paul M. Coen, Nicholaas Bohnen
| Wiley Online Library Verified
Performance fatigability, the degree one is limited by fatigue during a walking task, is an established measure of impairment in older adults (Enoka et al. 2021; Van Geel et al. 2020) and a subclinical indicator of functional limitations (Schnelle et al. 2012; Hunter 2018; Qiao et al. 2023). Performance fatigability is a subclinical indicator of impending functional decline in older adults (Schrack et al. 2020).
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