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Abstract Multipolar mitotic spindles with extra centrosomes, first observed in cancer cells in the late nineteenth century, remain poorly understood. Here, to address how cells overcome proliferation arrest imposed by centrosome amplification, we describe a genome-wide screen revealing that downregulation of the Wnt, Hippo, Tpr53, PIDDosome, ciliary biogenesis, or autophagy pathways enables proliferation of mouse embryonic stem cells having PLK4-mediated centrosome amplification.

Abstract Advances in AI are transforming scientific discovery, yet spatial biology, a field that deciphers the molecular organization within tissues, remains constrained by labor-intensive workflows. Here, we present SpatialAgent, a fully autonomous AI agent dedicated for spatial-biology research. SpatialAgent integrates large language models with dynamic tool execution and adaptive reasoning.

Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-024-02391-0, published online 7 October 2024. In the version of this article initially published, the Supplementary Information did not include vector information for CROPseq-puro-v2 or reagent information for CROPseq-Guide-Puro and CROPseq-puro-v2. The Supplementary Information accompanying the HTML version of the article has been amended. About this article Kudo, T., Meireles, A.M., Moncada, R. et al.