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Articles

Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter

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By Heng Zhang, Helmut Schmidhammer, Tye I. Gonzalez, Cosmin I. Ciotu, Nataša Tomašević, Johannes Koehbach, Paula Schwarz, Gabor Tajti, Simon Hasinger, Nina Kastner, Orcun Avsar, Yi Jiang, Roland Hellinger, Michael Fischer Verified, K. Johan Rosengren, Christian W. Gruber, Aaron Villaraza, Thomas Stockner, Mariana Spetea, H. Xu, Harald H. Sitte, Oliver J. V. Belleza, Carlo Martin M. Ocampo, Jomari C. Fernando, Mounaf Al Makhlouf, Bernhard Retzl, Kathrin Jäntsch
| Nature Verified
Abstract The χ-conotoxins are venom-derived peptides that specifically target the noradrenaline transporter (also known as norepinephrine transporter, NET). Regulation of noradrenergic signaling by NET affects neurophysiological processes, including pain. Therefore, the χ-conotoxin MrIA and its synthetic analogs have been previously investigated for their analgesic activity.
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