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Paula Tabares on Muck Rack

Paula Tabares

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Articles

Short-term cytokine stimulation reveals regulatory T-cells with down-regulated Foxp3 expression in human peripheral blood

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By Birgit Sawitzki, Hans-Peter Tony, Paula Tabares, Susanne Berr, Daniela Langenhorst, Thomas Hünig
| Color Research & Application Verified
The identification of regulatory T cells (Treg cells) in human peripheral blood is an important tool in diagnosis, research and therapeutic intervention. As compared to lymphoid tissues, the frequencies of circulating Treg cells identified as CD4+CD25+Foxp3+ are, however, low. We here show that many of these cells remain undetected due to transient down regulation of Foxp3, which rapidly decays in the absence of cytokine-mediated STAT5 signals.
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